Cannabinoid Receptor
Cannabinoid Receptor
Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.
Cannabinoid Receptor Isoform Specific Products
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Cannabinoid Receptor Inhibitors
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Cannabinoid Receptor Activators
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Cannabinoid Receptor Modulators
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Cannabinoid Receptor Chemical
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Cannabinoid Receptor Inducer
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Cannabinoid Receptor Degrader
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Cannabinoid Receptor Controls
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Cannabinoid Receptor Ligands
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Cannabinoid Receptor Related Products (449)
Related Products (449)
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Antibodies (1)
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Cannabinoid Receptor Isoform Comparison
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FDU-PB-22
0 ImagesCat. No.: HY-114663CAS No.: 1883284-94-3FDU-PB-22 is a new synthetic cannabinoid that is rapidly metabolized in HLM, with a half-life of 12.4 minutes.
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9β,10β-epoxy Hexahydrocannabinol
0 ImagesCat. No.: HY-179436CAS No.: 1781270-07-2Synonyms: 9β,10β-EHHC; 9β,10β-epoxy HHC9β,10β-epoxy Hexahydrocannabinol is a cannabinoid receptor 1 (CB1) and CB2 receptor ligand with a binding affinity of 224 nM for CB1 and 335 nM for CB2. 9β,10β-epoxy Hexahydrocannabinol reduces locomotor activity, induces catalepsy, lowers body temperature, and produces antinociceptive effects in mice. 9β,10β-epoxy Hexahydrocannabinol can be used for the study of nervous system diseases.
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Pregnenolone monosulfate sodium-13C2,d2
0 ImagesCat. No.: HY-110189SCAS No.: 2483824-22-0Synonyms: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium-13C2,d2Pregnenolone monosulfate (sodium)-13C2,d2 is the 13C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
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AM11638
0 ImagesCat. No.: HY-176544CAS No.: 3054510-97-0
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PQM-244
0 ImagesCat. No.: HY-174848CAS No.: 316139-50-1PQM-244 (Compound 5c) is an orally active and multi-target modulator of TRPV1 and CB1 and CB2 receptors. PQM-244 has significant peripheral antinociceptive effects on both neurogenic and inflammatory phases. PQM-244 also has potential antioxidant activity with an IC50 of 14.15 µM for radical scavenging DPPH. PQM-244 can be used for chronic pain and inflammatory disease research, such as diabetes, atherosclerosis and Alzheimer’s disease.
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COR170
0 ImagesCat. No.: HY-103331CAS No.: 1048039-15-1
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CB1-IN-2
0 ImagesCat. No.: HY-147821CAS No.: 2527805-39-4CB1-IN-2 (Compound 4g) is a selective CB1 inhibitor with an IC50 of 0.644 μM. CB1-IN-2 can penetrates BBB and might cause CNS side effect similar with Rimonabant.
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Pirnabine
0 ImagesCat. No.: HY-152270CAS No.: 19825-63-9Pirnabine is a cannabinoid receptor ligand. Pirnabine can be used for the research of glaucoma.
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Nervonoyl ethanolamide
0 ImagesCat. No.: HY-145475CAS No.: 887405-21-2Synonyms: NEANervonoyl ethanolamide (NEA) is an endogenous cannabinoid that can act as a presynaptic and postsynaptic neuromodulator. Nervonoyl ethanolamide can also be used in the research of inflammation.
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CB2R agonist 4
0 ImagesCat. No.: HY-175481CAS No.: 182496-82-8CB2R agonist 4 is a cannabinoid receptor 2 (CB2R) agonist with an EC50 value of 6.9 μM. CB2R agonist 4 can induce cell apoptosis, ROS production and protein misfolding. CB2R agonist 4 shows cytotoxicity to a panel of tumor cell lines. CB2R agonist 4 can be used for the research of cancer.
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AB-FUBINACA 3-fluorobenzyl isomer
0 ImagesCat. No.: HY-114880CAS No.: 1185282-19-2AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid that belongs to the indole derivatives and has a high affinity for the central CB1 receptors (Ki= 0.9 nM), exhibiting anticonvulsant activity.
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Prostaglandin E2-1-glyceryl ester
0 ImagesCat. No.: HY-114826CAS No.: 37497-47-5Synonyms: PGE2-1-glyceyl esterProstaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
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GPX4-IN-18
0 ImagesCat. No.: HY-175041CAS No.: 3016433-00-1GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4). GPX4-IN-18 is also an inducer of ferroptosis. GPX4-IN-18 can increase the production of ROS and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal cell carcinoma cells. GPX4-IN-18 induces ferroptosis in HT-1080 cells with IC50s of 0.007 μM (absence of ferrostatin-1) and 1.486 μM (presence of ferrostatin-1). GPX4-IN-18 reduces in vivo tumor volume and intratumoral GPX4 levels in OS-RC-2 xenograft murine model.
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SGC stimulator 2
0 ImagesCat. No.: HY-187209CAS No.: 1350852-88-8SGC stimulator 2 is an orally active soluble guanylyl cyclase (sGC) stimulator with an EC50 of 44 nM. SGC stimulator 2 exhibits inhibitory activity against the CB2 receptor, with an IC50 of 2.7 μM. SGC stimulator 2 activates native (Fe2+) sGC in a heme-dependent manner. SGC stimulator 2 produces sustained hypotensive effects in animal models. SGC stimulator 2 can be used for the research of hypertension.
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O-Arachidonoyl glycidol-d5
0 ImagesCat. No.: HY-W742940CAS No.: 2519458-54-7O-Arachidonoyl glycidol-d5 is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC50 value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC50s of 19, 12 μM, respectively.
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AM8936
0 ImagesCat. No.: HY-144827CAS No.: 2820337-96-8AM8936 acts as a balanced and potent cannabinoid receptor type-1 (CB1) agonist in functional assays (EC50s of 8.6 and 1.4 nM for rCB1 and hCB1, respectively). AM8936 exhibits high affinity for rat CB1 (rCB1) with Ki of 0.55 nM. AM8936 is a potent and efficacious CB1 agonist in vivo. AM8936 can be used for the research of CNS and metabolic disorders, pain, glaucoma, etc.
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N-Arachidonyldopamine-d8
0 ImagesCat. No.: HY-110018SCAS No.: 1159908-42-5N-Arachidonyldopamine-d8 is the deuterium labeled N-Arachidonyldopamine.
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Hemopressin(rat) TFA
0 ImagesCat. No.: HY-P1090ACAS No.: 1431329-47-3Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models.
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Glutaminyl cyclase/CB2R modulator-1
0 ImagesCat. No.: HY-187205CAS No.: 3105939-80-5Glutaminyl cyclase/CB2R modulator-1 (Compound 18) acts as an inhibitor of glutaminyl cyclase (QC) (IC50 = 0.65 μM) and an agonist of cannabinoid receptor type 2 (CB2R) (EC50 = 0.32 μM). Glutaminyl cyclase/CB2R modulator-1 can be used for the research of Alzheimer's disease.
